| Year | Round | Pick | Player | Surname | Forename | Team | Pos | College | Notes | |
| 1981 | 1 | 1 | 1 | Rogers | George | NO | RB | South Carolina | ||
| 1981 | 1 | 2 | 2 | Taylor | Lawrence | NYG | LB | North Carolina | ||
| 1981 | 1 | 3 | 3 | McNeil | Freeman | NYJ | RB | UCLA | ||
| 1981 | 1 | 4 | 4 | Easley | Kenny | SEA | DB | UCLA | ||
| 1981 | 1 | 5 | 5 | Junior | E.J. | STL | LB | Alabama | ||
| 1981 | 1 | 6 | 6 | Campbell | Rich | GB | QB | California | ||
| 1981 | 1 | 7 | 7 | Green | Hugh | TB | LB | Pittsburgh | ||
| 1981 | 1 | 8 | 8 | Lott | Ronnie | SF | DB | USC | ||
| 1981 | 1 | 9 | 9 | Owens | Mel | LA | LB | Michigan | ||
| 1981 | 1 | 10 | 10 | Verser | David | CIN | WR | Kansas | ||
| 1981 | 1 | 11 | 11 | Van Horne | Keith | CHI | T | USC | ||
| 1981 | 1 | 12 | 12 | McMillan | Randy | BAL | RB | Pittsburgh | ||
| 1981 | 1 | 13 | 13 | Overstreet | David | MIA | RB | Oklahoma | ||
| 1981 | 1 | 14 | 14 | Scott | Willie | KC | TE | South Carolina | ||
| 1981 | 1 | 15 | 15 | Smith | Dennis | DEN | DB | USC | ||
| 1981 | 1 | 16 | 16 | Nichols | Mark | DET | WR | San Jose State | ||
| 1981 | 1 | 17 | 17 | Gary | Keith | PIT | DE | Oklahoma | ||
| 1981 | 1 | 18 | 18 | Thompson | Donnell | BAL | DT | North Carolina | ||
| 1981 | 1 | 19 | 19 | Holloway | Brian | NE | T | Stanford | ||
| 1981 | 1 | 20 | 20 | May | Mark | WAS | T | Pittsburgh | ||
| 1981 | 1 | 21 | 21 | Watts | Ted | OAK | DB | Texas Tech | ||
| 1981 | 1 | 22 | 22 | Dixon | Hanford | CLE | DB | Southern Mississippi | ||
| 1981 | 1 | 23 | 23 | Marsh | Curt | OAK | T | Washington | ||
| 1981 | 1 | 24 | 24 | Brooks | James | SD | RB | Auburn | ||
| 1981 | 1 | 25 | 25 | Butler | Bobby | ATL | DB | Florida State | ||
| 1981 | 1 | 26 | 26 | Richards | Howard | DAL | T | Missouri | ||
| 1981 | 1 | 27 | 27 | Mitchell | Leonard | PHI | DE | Houston | ||
| 1981 | 1 | 28 | 28 | Moore | Booker | BUF | RB | Penn State | ||
| 1981 | 2 | 1 | 29 | Gary | Russell | NO | DB | Nebraska | ||
| 1981 | 2 | 2 | 30 | Barber | Marion | NYJ | RB | Minnesota | ||
| 1981 | 2 | 3 | 31 | Hughes | David | SEA | RB | Boise State | ||
| 1981 | 2 | 4 | 32 | Young | Dave | NYG | TE | Purdue | ||
| 1981 | 2 | 5 | 33 | Lomax | Neil | STL | QB | Portland State | ||
| 1981 | 2 | 6 | 34 | Wilder | James | TB | RB | Missouri | ||
| 1981 | 2 | 7 | 35 | Lewis | Gary | GB | TE | Texas-Arlington | ||
| 1981 | 2 | 8 | 36 | Harty | John | SF | DT | Iowa | ||
| 1981 | 2 | 9 | 37 | Collinsworth | Cris | CIN | WR | Florida | ||
| 1981 | 2 | 10 | 38 | Singletary | Mike | CHI | LB | Baylor | ||
| 1981 | 2 | 11 | 39 | McDole | Mardye | MIN | WR | Mississippi State | ||
| 1981 | 2 | 12 | 40 | Wright | Eric | SF | DB | Missouri | ||
| 1981 | 2 | 13 | 41 | Delaney | Joe | KC | RB | Northwest Louisiana | ||
| 1981 | 2 | 14 | 42 | Brown | Clay | DEN | TE | Brigham Young | ||
| 1981 | 2 | 15 | 43 | Collins | Jim | LA | LB | Syracuse | ||
| 1981 | 2 | 16 | 44 | Washington | Anthony | PIT | DB | Fresno State | ||
| 1981 | 2 | 17 | 45 | Sendlein | Robin | MIN | LB | Texas | ||
| 1981 | 2 | 18 | 46 | Green | Curtis | DET | DE | Alabama State | ||
| 1981 | 2 | 19 | 47 | Collins | Tony | NE | RB | East Carolina | ||
| 1981 | 2 | 20 | 48 | Long | Howie | OAK | DT | Villanova | ||
| 1981 | 2 | 21 | 49 | Williams | Chris | BUF | DB | Louisiana State | ||
| 1981 | 2 | 22 | 50 | Franklin | Byron | BUF | WR | Auburn | ||
| 1981 | 2 | 23 | 51 | Jackson | Ricky | NO | LB | Pittsburgh | ||
| 1981 | 2 | 24 | 52 | Redwine | Jarvis | MIN | RB | Nebraska | ||
| 1981 | 2 | 25 | 53 | Donley | Doug | DAL | WR | Ohio State | ||
| 1981 | 2 | 26 | 54 | White | Lyman | ATL | LB | Louisiana State | ||
| 1981 | 2 | 27 | 55 | Miraldi | Dean | PHI | G | Utah | ||
| 1981 | 2 | 28 | 56 | Franklin | Andra | MIA | RB | Nebraska | ||
| 1981 | 3 | 1 | 57 | Warren | Frank | NO | DE | Auburn | ||
| 1981 | 3 | 2 | 58 | Dugan | Bill | SEA | G | Penn State | ||
| 1981 | 3 | 3 | 59 | Mistler | John | NYG | WR | Arizona State | ||
| 1981 | 3 | 4 | 60 | Rudolph | Ben | NYJ | DT | Long Beach State | ||
| 1981 | 3 | 5 | 61 | Griffin | Jeff | STL | DB | Utah | ||
| 1981 | 3 | 6 | 62 | Stachowicz | Ray | GB | P | Michigan State | ||
| 1981 | 3 | 7 | 63 | Meisner | Greg | LA | DT | Pittsburgh | ||
| 1981 | 3 | 8 | 64 | Simmons | John | CIN | DB | Southern Methodist | ||
| 1981 | 3 | 9 | 65 | Williamson | Carlton | SF | DB | Pittsburgh | ||
| 1981 | 3 | 10 | 66 | Cobb | Robert | LA | DE | Arizona | ||
| 1981 | 3 | 11 | 67 | Margerum | Ken | CHI | WR | Stanford | ||
| 1981 | 3 | 12 | 68 | Van Divier | Randy | BAL | T | Washington | ||
| 1981 | 3 | 13 | 69 | Grimm | Russ | WAS | C | Pittsburgh | ||
| 1981 | 3 | 14 | 70 | Harvey | Marvin | KC | TE | Southern Mississippi | ||
| 1981 | 3 | 15 | DEN | pick forfeited | ||||||
| 1981 | 3 | 16 | 71 | Brenner | Hoby | NO | TE | USC | ||
| 1981 | 3 | 17 | 72 | Greco | Don | DET | G | Western Illinois | ||
| 1981 | 3 | 18 | 73 | Donnalley | Rick | PIT | C | North Carolina | ||
| 1981 | 3 | 19 | 74 | Irwin | Tim | MIN | T | Tennessee | ||
| 1981 | 3 | 20 | 75 | Taylor | Roger | KC | T | Oklahoma State | ||
| 1981 | 3 | 21 | 76 | Mosley | Mike | BUF | WR | Texas A&M | ||
| 1981 | 3 | 22 | 77 | Phillips | Irvin | SD | DB | Arkansas Tech | ||
| 1981 | 3 | 23 | 78 | Burress | Lloyd | KC | DB | Maryland | ||
| 1981 | 3 | 24 | 79 | Holston | Michael | HOU | WR | Morgan State | ||
| 1981 | 3 | 25 | 80 | Woerner | Scott | ATL | DB | Georgia | ||
| 1981 | 3 | 26 | 81 | Titensor | Glen | DAL | DE | Brigham Young | ||
| 1981 | 3 | 27 | 82 | LaFleur | Greg | PHI | TE | Louisiana State | ||
| 1981 | 3 | 28 | 83 | Geathers | Robert | BUF | DT | South Carolina State | ||
| 1981 | 4 | 1 | 84 | Greene | Sam | MIA | WR | UNLV | ||
| 1981 | 4 | 2 | 85 | Chatman | Clifford | NYG | RB | Central State (OK) | ||
| 1981 | 4 | 3 | 86 | Washington | Al | NYJ | LB | Ohio State | ||
| 1981 | 4 | 4 | 87 | Phillips | Scott | SEA | WR | Brigham Young | ||
| 1981 | 4 | 5 | 88 | Rhodes | Steve | STL | WR | Oklahoma | ||
| 1981 | 4 | 6 | 89 | Holt | John | TB | DB | West Texas State | ||
| 1981 | 4 | 7 | 90 | Flick | Tom | WAS | QB | Washington | ||
| 1981 | 4 | 8 | 91 | Pelluer | Scott | DAL | LB | Washington State | ||
| 1981 | 4 | 9 | 92 | Robinson | Mike | CLE | DE | Arizona | ||
| 1981 | 4 | 10 | 93 | Grazier | Guy | CIN | LB | Wyoming | ||
| 1981 | 4 | 11 | 94 | Sherwin | Tim | BAL | TE | Boston College | ||
| 1981 | 4 | 12 | 95 | Bell | Todd | CHI | DB | Ohio State | ||
| 1981 | 4 | 13 | 96 | Wright | Brad | MIA | QB | New Mexico | ||
| 1981 | 4 | 14 | 97 | Washington | Ron | KC | WR | Arizona State | ||
| 1981 | 4 | 15 | 98 | Herrmann | Mark | DEN | QB | Purdue | ||
| 1981 | 4 | 16 | 99 | Porter | Tracy | DET | WR | Louisiana State | ||
| 1981 | 4 | 17 | 100 | Martin | Robbie | PIT | WR | Cal Poly-San Luis Obispo | ||
| 1981 | 4 | 18 | 101 | Swain | John | MIN | DB | Miami (FL) | ||
| 1981 | 4 | 19 | 102 | Blackmon | Don | NE | LB | Tulsa | ||
| 1981 | 4 | 20 | 103 | Lawrence | Amos | SD | RB | North Carolina | ||
| 1981 | 4 | 21 | 104 | Lilja | George | LA | C | Michigan | ||
| 1981 | 4 | 22 | 105 | Turner | Richard | GB | DT | Oklahoma | ||
| 1981 | 4 | 23 | 106 | Eyre | Nick | HOU | T | Brigham Young | ||
| 1981 | 4 | 24 | 107 | Sievers | Eric | SD | TE | Maryland | ||
| 1981 | 4 | 25 | 108 | Nelson | Derrie | DAL | LB | Nebraska | ||
| 1981 | 4 | 26 | 109 | Scully | John | ATL | C | Notre Dame | ||
| 1981 | 4 | 27 | 110 | Murray | Calvin | PHI | RB | Ohio State | ||
| 1981 | 4 | 28 | 111 | Robinson | Johnny | OAK | DT | Louisiana Tech | ||
| 1981 | 5 | 1 | 112 | Orbre | Louis | NO | T | Oklahoma | ||
| 1981 | 5 | 2 | 113 | Keys | Tyrone | NYJ | DE | Mississippi State | ||
| 1981 | 5 | 3 | 114 | Bailey | Edwin | SEA | G | South Carolina State | ||
| 1981 | 5 | 4 | 115 | Neill | Bill | NYG | DT | Pittsburgh | ||
| 1981 | 5 | 5 | 116 | Gillen | John | STL | LB | Illinois | ||
| 1981 | 5 | 6 | 117 | Braggs | Byron | GB | DT | Alabama | ||
| 1981 | 5 | 7 | 118 | Davis | James | OAK | DB | Southern | ||
| 1981 | 5 | 8 | 119 | Manley | Dexter | WAS | DE | Oklahoma State | ||
| 1981 | 5 | 9 | 120 | Pryor | Benjie | CIN | TE | Pittsburgh | ||
| 1981 | 5 | 10 | 121 | Thomas | Lynn | SF | DB | Pittsburgh | ||
| 1981 | 5 | 11 | 122 | Jones | Arrington | SF | RB | Winston-Salem State | ||
| 1981 | 5 | 12 | 123 | Ray | Wendell | MIN | DE | Missouri | ||
| 1981 | 5 | 13 | 124 | Thomas | Todd | KC | T | North Dakota | ||
| 1981 | 5 | 14 | 125 | Lanier | Ken | DEN | T | Florida State | ||
| 1981 | 5 | 15 | 126 | Poole | Ken | MIA | DE | N.E. Louisiana | ||
| 1981 | 5 | 16 | 127 | Martin | Ricky | PIT | WR | New Mexico | ||
| 1981 | 5 | 17 | 128 | Boyarsky | Jerry | NO | DT | Pittsburgh | ||
| 1981 | 5 | 18 | 129 | Lee | Larry | DET | G | UCLA | ||
| 1981 | 5 | 19 | 130 | Clark | Steve | NE | DT | Kansas State | ||
| 1981 | 5 | 20 | 131 | Ferguson | Keith | SD | LB | Ohio State | ||
| 1981 | 5 | 21 | 132 | Sayre | Gary | WAS | G | Cameron | ||
| 1981 | 5 | 22 | 133 | Fowler | Delbert | HOU | LB | West Virginia | ||
| 1981 | 5 | 23 | 134 | Cox | Steve | CLE | P | Arkansas | ||
| 1981 | 5 | 24 | 135 | Clark | Calvin | BUF | DE | Purdue | ||
| 1981 | 5 | 25 | 136 | Sanders | Eric | ATL | T | Nevada | ||
| 1981 | 5 | 26 | 137 | Spradlin | Danny | DAL | LB | Tennessee | ||
| 1981 | 5 | 27 | 138 | Vigorito | Tommy | MIA | RB | Virginia | ||
| 1981 | 5 | 28 | pick forfeited | OAK | pick forfeited | |||||
| 1981 | 6 | 1 | 139 | Hudson | Nat | NO | G | Georgia | ||
| 1981 | 6 | 2 | 140 | Durham | Steve | SEA | DE | Clemson | ||
| 1981 | 6 | 3 | 141 | Gissinger | Andy | SD | T | Syracuse | ||
| 1981 | 6 | 4 | 142 | Woodring | John | NYJ | LB | Brown | ||
| 1981 | 6 | 5 | 143 | Ahrens | Dave | STL | LB | Wisconsin | ||
| 1981 | 6 | 6 | 144 | Poe | Johnnie | NO | DB | Missouri | ||
| 1981 | 6 | 7 | 145 | Hoover | Mel | NYG | WR | Arizona State | ||
| 1981 | 6 | 8 | 146 | Robinson | Rex | CIN | K | Georgia | ||
| 1981 | 6 | 9 | 147 | Kugler | Pete | SF | DT | Penn State | ||
| 1981 | 6 | 10 | 148 | Kubin | Larry | WAS | LB | Penn State | ||
| 1981 | 6 | 11 | 149 | Green | Bubba | BAL | DT | North Carolina State | ||
| 1981 | 6 | 12 | 150 | Henderson | Reuben | CHI | DB | San Diego State | ||
| 1981 | 6 | 13 | 151 | Lewis | Alvin | DEN | RB | Colorado State | ||
| 1981 | 6 | 14 | 152 | Moore | Mack | MIA | DE | Texas A&M | ||
| 1981 | 6 | 15 | 153 | Luckie | Dock | KC | DT | Florida | ||
| 1981 | 6 | 16 | 154 | Walker | Fulton | MIA | DB | West Virginia | ||
| 1981 | 6 | 17 | 155 | Johnson | Sam | DET | DB | Maryland | ||
| 1981 | 6 | 18 | 156 | Hinkle | Bryan | PIT | LB | Oregon | ||
| 1981 | 6 | 19 | 157 | Wooten | Ron | NE | G | North Carolina | ||
| 1981 | 6 | 20 | 158 | Daniels | William | LA | DT | Alabama State | ||
| 1981 | 6 | 21 | 159 | Kay | Bill | HOU | DB | Purdue | ||
| 1981 | 6 | 22 | 160 | Simmons | Ron | CLE | DT | Florida State | ||
| 1981 | 6 | 23 | 161 | Holt | Robert | BUF | WR | Baylor | ||
| 1981 | 6 | 24 | 162 | Duckworth | Bobby | SD | WR | Arkansas | ||
| 1981 | 6 | 25 | 163 | Skillings | Vince | DAL | DB | Ohio State | ||
| 1981 | 6 | 26 | 164 | Standback | Harry | ATL | DT | North Carolina | ||
| 1981 | 6 | 27 | 165 | O'Neal | Edward | NYG | RB | Tuskegee | ||
| 1981 | 6 | 28 | 166 | Redd | Glen | NO | LB | Brigham Young | ||
| 1981 | 7 | 1 | 167 | Williams | Kevin | NO | WR | USC | ||
| 1981 | 7 | 2 | 168 | Jackson | Louis | NYG | RB | Cal Poly-San Luis Obispo | ||
| 1981 | 7 | 3 | 169 | Neil | Kenny | NYJ | DE | Iowa State | ||
| 1981 | 7 | 4 | 170 | Johnson | Ron | SEA | WR | Long Beach State | ||
| 1981 | 7 | 5 | 171 | Donnalley | Kevin | STL | DB | North Dakota State | ||
| 1981 | 7 | 6 | 172 | Whitaker | Bill | GB | DB | Missouri | ||
| 1981 | 7 | 7 | 173 | Fellows | Ron | DAL | DB | Missouri | ||
| 1981 | 7 | 8 | 174 | Duncan | Alan | PHI | K | Tennessee | ||
| 1981 | 7 | 9 | 175 | Battle | Ron | LA | TE | North Texas State | ||
| 1981 | 7 | 10 | 176 | Schuh | Jeff | CIN | LB | Minnesota | ||
| 1981 | 7 | 11 | 177 | Fisher | Jeff | CHI | DB | USC | ||
| 1981 | 7 | 12 | 178 | Ariri | Obed | BAL | K | Clemson | ||
| 1981 | 7 | 13 | 179 | Daum | Mike | MIA | T | Cal Poly-San Luis Obispo | ||
| 1981 | 7 | 14 | 180 | Jackson | Billy | KC | RB | Alabama | ||
| 1981 | 7 | 15 | 181 | Busick | Steve | DEN | LB | USC | ||
| 1981 | 7 | 16 | 182 | Spivey | Lee | DET | T | Southern Methodist | ||
| 1981 | 7 | 17 | 183 | Little | David | PIT | LB | Florida | ||
| 1981 | 7 | 18 | 184 | Shaver | Don | MIN | RB | Kutztown (PA) | ||
| 1981 | 7 | 19 | 185 | Toler | Ken | NE | WR | Mississippi | ||
| 1981 | 7 | 20 | 186 | Scovill | Brad | SEA | TE | Penn State | ||
| 1981 | 7 | 21 | 187 | Johnson | Eddie | CLE | LB | Louisiana Tech | ||
| 1981 | 7 | 22 | 188 | Doolittle | Steve | BUF | LB | Colorado State | ||
| 1981 | 7 | 23 | 189 | Holohan | Pete | SD | TE | Notre Dame | ||
| 1981 | 7 | 24 | 190 | Clark | Mike | LA | DE | Florida | ||
| 1981 | 7 | 25 | ATL | Pick used in 1980 supplemental draft | ||||||
| 1981 | 7 | 26 | 191 | Miller | Ken | DAL | DB | Eastern Michigan | ||
| 1981 | 7 | 27 | 192 | Field | Doak | PHI | LB | Baylor | ||
| 1981 | 7 | 28 | 193 | Washington | Don | HOU | DB | Texas A&I | ||
| 1981 | 8 | 1 | 194 | Naber | Ken | NE | K | Stanford | ||
| 1981 | 8 | 2 | 195 | Jones | Lloyd | NYJ | WR | Brigham Young | ||
| 1981 | 8 | 3 | 196 | Lane | Eric | SEA | RB | Brigham Young | ||
| 1981 | 8 | 4 | 197 | Powers | John | NYG | G | Michigan | ||
| 1981 | 8 | 5 | 198 | Fisher | Mike | STL | WR | Baylor | ||
| 1981 | 8 | 6 | 199 | Johnson | Denver | TB | T | Tulsa | ||
| 1981 | 8 | 7 | 200 | Werts | Larry | GB | LB | Jackson State | ||
| 1981 | 8 | 8 | 201 | Brown | Charlie | WAS | WR | South Carolina State | ||
| 1981 | 8 | 9 | 202 | Kemp | Bobby | CIN | DB | Fullerton State | ||
| 1981 | 8 | 10 | 203 | White | Garry | SF | RB | Minnesota | ||
| 1981 | 8 | 11 | 204 | Sitton | Ken | BAL | DB | Oklahoma | ||
| 1981 | 8 | 12 | 205 | Zettek | Scott | CHI | DT | Notre Dame | ||
| 1981 | 8 | 13 | 206 | Dorn | David | KC | WR | Rutgers | ||
| 1981 | 8 | 14 | 207 | Reed | Mark | NYG | QB | Morehead State | ||
| 1981 | 8 | 15 | 208 | Judson | William | MIA | DB | South Carolina State | ||
| 1981 | 8 | 16 | 209 | Wilson | Frank | PIT | RB | Rice | ||
| 1981 | 8 | 17 | 210 | Wilson | Wade | MIN | QB | East Texas State | ||
| 1981 | 8 | 18 | 211 | Niziolek | Bob | DET | TE | Colorado | ||
| 1981 | 8 | 19 | 212 | Dawson | Lin | NE | TE | North Carolina State | ||
| 1981 | 8 | 20 | 213 | Watts | J.C. | NYJ | DB | Oklahoma | ||
| 1981 | 8 | 21 | 214 | Gladys | Gene | NO | LB | Penn State | ||
| 1981 | 8 | 22 | 215 | Eavns | Kevin | NO | DB | Arkansas | ||
| 1981 | 8 | 23 | 216 | Plunkett | Art | LA | T | UNLV | ||
| 1981 | 8 | 24 | 217 | Tullis | Willie | HOU | WR | Troy State | ||
| 1981 | 8 | 25 | 218 | Piurowski | Paul | DAL | LB | Florida State | ||
| 1981 | 8 | 26 | 219 | Toney | Cliff | ATL | DB | Auburn | ||
| 1981 | 8 | 27 | 220 | Taylor | Hosea | BAL | DT | Houston | ||
| 1981 | 8 | 28 | 221 | Ard | Bill | NYG | G | Wake Forest | ||
| 1981 | 9 | 1 | 222 | Tyler | Toussaint | NO | RB | Washington | ||
| 1981 | 9 | 2 | 223 | Stone | Jim | SEA | RB | Notre Dame | ||
| 1981 | 9 | 3 | 224 | Hunt | Byron | NYG | LB | Southern Methodist | ||
| 1981 | 9 | 4 | 225 | Larry | Admiral Dewey | NYJ | DB | UNLV | ||
| 1981 | 9 | 5 | 226 | Mitchell | Stump | STL | RB | Citadel | ||
| 1981 | 9 | 6 | 227 | Huffman | Tim | GB | T | Notre Dame | ||
| 1981 | 9 | 7 | 228 | Ford | Mike | TB | QB | Southern Methodist | ||
| 1981 | 9 | 8 | 229 | Hannula | Jim | CIN | T | Northern Illinois | ||
| 1981 | 9 | 9 | 230 | Samoa | Samoa | CIN | RB | Washington State | ||
| 1981 | 9 | 10 | 231 | Grant | Darryl | WAS | G | Rice | ||
| 1981 | 9 | 11 | 232 | Ditta | Frank | CHI | G | Baylor | ||
| 1981 | 9 | 12 | 233 | Gooch | Tim | BAL | DT | Kentucky | ||
| 1981 | 9 | 13 | 234 | Olsen | Rusty | DEN | DE | Washington | ||
| 1981 | 9 | 14 | 235 | Noonan | John | MIA | WR | Nebraska | ||
| 1981 | 9 | 15 | 236 | Whatley | Jim | SEA | WR | Washington State | ||
| 1981 | 9 | 16 | 237 | Vereen | Tony | KC | DB | Southeastern Louisiana | ||
| 1981 | 9 | 17 | 238 | Jernigan | Hugh | DET | DB | Arkansas | ||
| 1981 | 9 | 18 | 239 | Hunter | James | PIT | T | USC | ||
| 1981 | 9 | 19 | 240 | Martin | Dave | DET | DB | Villanova | ||
| 1981 | 9 | 20 | 241 | Riddick | Rob | BUF | RB | Millersville (PA) | ||
| 1981 | 9 | 21 | 242 | Seawell | Ron | LA | LB | Portland State | ||
| 1981 | 9 | 22 | 243 | Riley | Avon | HOU | LB | UCLA | ||
| 1981 | 9 | 23 | 244 | Schleusener | Randy | CLE | G | Nebraska | ||
| 1981 | 9 | 24 | SD | Pick used in 1980 supplemental draft | ||||||
| 1981 | 9 | 25 | 245 | Fance | Calvin | ATL | RB | Rice | ||
| 1981 | 9 | 26 | 246 | Wilson | Mike | DAL | WR | Washington State | ||
| 1981 | 9 | 27 | 247 | Commiskey | Chuck | PHI | DB | Mississippi | ||
| 1981 | 9 | 28 | 248 | Mohl | Curt | OAK | T | UCLA | ||
| 1981 | 10 | 1 | 249 | Gajan | Hokie | NO | RB | Louisiana State | ||
| 1981 | 10 | 2 | 250 | Barker | Mike | NYG | DT | Grambling | ||
| 1981 | 10 | 3 | 251 | Wetzel | Marty | NYJ | LB | Tulane | ||
| 1981 | 10 | 4 | 252 | Dawson | Ken | SEA | RB | Savannah State | ||
| 1981 | 10 | 5 | 253 | Mallard | James | STL | WR | Alabama | ||
| 1981 | 10 | 6 | 254 | McCune | Ken | TB | DE | Texas | ||
| 1981 | 10 | 7 | 255 | Hall | Nickie | GB | QB | Tulane | ||
| 1981 | 10 | 8 | 256 | Gerken | Gregg | BAL | LB | Northern Arizona | ||
| 1981 | 10 | 9 | 257 | Kessel | Phil | WAS | QB | Northern Michigan | ||
| 1981 | 10 | 10 | 258 | Simpson | Hubert | CIN | RB | Tennessee | ||
| 1981 | 10 | 11 | 259 | Bryant | Trent | BAL | DB | Arkansas | ||
| 1981 | 10 | 12 | 260 | Clifford | Tim | CHI | QB | Indiana | ||
| 1981 | 10 | 13 | 261 | Folsom | Steve | MIA | TE | Utah | ||
| 1981 | 10 | 14 | 262 | Studdard | Les | KC | G | Texas | ||
| 1981 | 10 | 15 | 263 | Joiner | Jim | STL | WR | Miami (FL) | ||
| 1981 | 10 | 16 | 264 | Cannavino | Andy | DET | LB | Michigan | ||
| 1981 | 10 | 17 | 265 | Mayock | Mike | PIT | DB | Boston College | ||
| 1981 | 10 | 18 | 266 | Murphy | James | MIN | WR | Utah State | ||
| 1981 | 10 | 19 | 267 | Kennedy | Allan | WAS | T | Washington State | ||
| 1981 | 10 | 20 | 268 | Parham | Robert | SD | RB | Grambling | ||
| 1981 | 10 | 21 | 269 | Alexander | Robert | LA | RB | West Virginia | ||
| 1981 | 10 | 22 | 270 | Jones | Larry | HOU | RB | Colorado State | ||
| 1981 | 10 | 23 | 271 | Prater | Dean | CLE | DE | Oklahoma State | ||
| 1981 | 10 | 24 | 272 | Cross | Justin | BUF | T | Western Colorado | ||
| 1981 | 10 | 25 | 273 | Graham | Pat | DAL | DT | California | ||
| 1981 | 10 | 26 | 274 | Murphy | Robert | ATL | DB | Ohio State | ||
| 1981 | 10 | 27 | 275 | Oliver | Hubert | PHI | RB | Arizona | ||
| 1981 | 10 | 28 | 276 | Hawkins | Frank | OAK | RB | Nevada | ||
| 1981 | 11 | 1 | 277 | Mickens | Lester | NO | WR | Kansas | ||
| 1981 | 11 | 2 | 278 | Gall | Ed | NYJ | DT | Maryland | ||
| 1981 | 11 | 3 | 279 | Olander | Lance | SEA | RB | Colorado | ||
| 1981 | 11 | 4 | 280 | Petrzelka | Matt | SD | T | Iowa | ||
| 1981 | 11 | 5 | 281 | Sherrod | Mike | STL | TE | Illinois | ||
| 1981 | 11 | 6 | 282 | Valora | Forrest | GB | LB | Oklahoma | ||
| 1981 | 11 | 7 | 283 | Smith | Johnny Ray | TB | DB | Lamar | ||
| 1981 | 11 | 8 | 284 | Hill | Jerry | WAS | WR | North Alabama | ||
| 1981 | 11 | 9 | 285 | Jackson | Robert | CIN | DB | Central Michigan | ||
| 1981 | 11 | 10 | 286 | DeBose | Rob | SF | TE | UCLA | ||
| 1981 | 11 | 11 | 287 | Johnson | Lonnie | CHI | RB | Indiana | ||
| 1981 | 11 | 12 | 288 | Smith | Holden | BAL | WR | California | ||
| 1981 | 11 | 13 | 289 | Case | Frank | KC | DE | Penn State | ||
| 1981 | 11 | 14 | 290 | Walker | Pat | DEN | WR | Miami (FL) | ||
| 1981 | 11 | 15 | 291 | Jensen | Jim | MIA | QB | Boston University | ||
| 1981 | 11 | 16 | 292 | Trocano | Rick | PIT | QB | Pittsburgh | ||
| 1981 | 11 | 17 | 293 | Stephanos | Bill | MIN | T | Boston College | ||
| 1981 | 11 | 18 | 294 | Jackson | Willie | DET | DB | Mississippi State | ||
| 1981 | 11 | 19 | 295 | Buckley | Brian | NE | QB | Harvard | ||
| 1981 | 11 | 20 | 296 | Greene | Marcellus | LA | DB | Arizona | ||
| 1981 | 11 | 21 | 297 | Matthews | Claude | HOU | G | Auburn | ||
| 1981 | 11 | 22 | 298 | Friday | Larry | CLE | DB | Mississippi State | ||
| 1981 | 11 | 23 | 299 | Barnett | Buster | BUF | TE | Jackson State | ||
| 1981 | 11 | 24 | 300 | Bradley | Carlos | SD | LB | Wake Forest | ||
| 1981 | 11 | 25 | 301 | Cahppelle | Keith | ATL | WR | Iowa | ||
| 1981 | 11 | 26 | 302 | Morrison | Tim | DAL | G | Georgia | ||
| 1981 | 11 | 27 | 303 | Davis | Gail | PHI | DT | Virginia Union | ||
| 1981 | 11 | 28 | 304 | Willis | Chester | OAK | RB | Auburn | ||
| 1981 | 12 | 1 | 305 | Wilks | Jim | NO | DT | San Diego State | ||
| 1981 | 12 | 2 | 306 | Bednarek | Jeff | SEA | DT | Pacific | ||
| 1981 | 12 | 3 | 307 | Maher | Mike | NYG | TE | Western Illinois | ||
| 1981 | 12 | 4 | 308 | Moeller | Mike | NYJ | T | Drake | ||
| 1981 | 12 | 5 | 309 | Adams | Joe | STL | G | Nebraska | ||
| 1981 | 12 | 6 | 310 | White | Brad | TB | DT | Tennessee | ||
| 1981 | 12 | 7 | 311 | Lewis | Cliff | GB | LB | Southern Mississippi | ||
| 1981 | 12 | 8 | 312 | O'Connell | Mark | CIN | QB | Ball State | ||
| 1981 | 12 | 9 | 313 | Ogilvie | Major | SF | RB | Alabama | ||
| 1981 | 12 | 10 | 314 | Didier | Clint | WAS | TE | Portland State | ||
| 1981 | 12 | 11 | 315 | Scoggins | Eric | BAL | LB | USC | ||
| 1981 | 12 | 12 | 316 | Shupryt | Bob | CHI | LB | New Mexico | ||
| 1981 | 12 | 13 | 317 | Hankerd | John | DEN | LB | Notre Dame | ||
| 1981 | 12 | 14 | 318 | Alford | John | MIA | DT | South Carolina State | ||
| 1981 | 12 | 15 | 319 | Gagliano | Bob | KC | QB | Utah State | ||
| 1981 | 12 | 16 | 320 | Williams | Brian | MIN | TE | Southern | ||
| 1981 | 12 | 17 | 321 | Robinson | Mandel | DEN | RB | Wyoming | ||
| 1981 | 12 | 18 | 322 | Adams | Joe | SF | QB | Tennessee State | ||
| 1981 | 12 | 19 | 323 | Crissy | Cris | NE | DB | Princeton | ||
| 1981 | 12 | 20 | 324 | Capece | Bill | HOU | K | Florida State | ||
| 1981 | 12 | 21 | 325 | McGill | Kevin | CLE | T | Oregon | ||
| 1981 | 12 | 22 | 326 | Clark | Keith | BUF | LB | Memphis State | ||
| 1981 | 12 | 23 | 327 | Charles | Stacy | SD | WR | Bethune-Cookman | ||
| 1981 | 12 | 24 | 328 | Penaranda | Jairo | LA | RB | UCLA | ||
| 1981 | 12 | 25 | 329 | Lundy | Nate | DAL | WR | Indiana | ||
| 1981 | 12 | 26 | 330 | McCants | Mark | ATL | DB | Temple | ||
| 1981 | 12 | 27 | 331 | Ellis | Ray | PHI | DB | Ohio State | ||
| 1981 | 12 | 28 | 332 | Nelson | Phil | OAK | TE | Delaware | ||