| Year | Round | Selec | Pick | Surname | Forename | Team | Pos | College | Notes | ||
| 2021 | 1 | 1 | 1 | Lawrence | Trevor | JAC | QB | Clemson | |||
| 2021 | 1 | 2 | 2 | Wilson | Zach | NYJ | QB | BYU | |||
| 2021 | 1 | 3 | 3 | Lance | Trey | SF | QB | North Dakota State | from Texans via Dolphins | ||
| 2021 | 1 | 4 | 4 | Pitts | Kyle | ATL | TE | Florida | |||
| 2021 | 1 | 5 | 5 | Chase | Ja’Marr | CIN | WR | LSU | |||
| 2021 | 1 | 6 | 6 | Waddle | Jaylen | MIA | WR | Alabama | from Eagles | ||
| 2021 | 1 | 7 | 7 | Sewell | Penei | DET | OT | Oregon | |||
| 2021 | 1 | 8 | 8 | Horn | Jaycee | CAR | CB | South Carolina | |||
| 2021 | 1 | 9 | 9 | Surtain | Patrick | DEN | CB | Alabama | |||
| 2021 | 1 | 10 | 10 | Smith | DeVonta | PHI | WR | Alabama | from Cowboys | ||
| 2021 | 1 | 11 | 11 | Fields | Justin | CHI | QB | Ohio State | from Giants | ||
| 2021 | 1 | 12 | 12 | Parsons | Micah | DAL | LB | Penn State | from Eagles via 49ers and Dolphins | ||
| 2021 | 1 | 13 | 13 | Slater | Rashawn | LAC | OT | Northwestern | |||
| 2021 | 1 | 14 | 14 | Vera-Tucker | Alijah | NYJ | OL | USC | from Vikings | ||
| 2021 | 1 | 15 | 15 | Jones | Mac | NE | QB | Alabama | |||
| 2021 | 1 | 16 | 16 | Collins | Zaven | ARI | LB | Tulsa | |||
| 2021 | 1 | 17 | 17 | Leatherwood | Alex | LV | OT | Alabama | |||
| 2021 | 1 | 18 | 18 | Phillips | Jaelan | MIA | DE | Miami | |||
| 2021 | 1 | 19 | 19 | Davis | Jamin | WAS | LB | Kentucky | |||
| 2021 | 1 | 20 | 20 | Toney | Kadarius | NYG | WR | Florida | from Bears | ||
| 2021 | 1 | 21 | 21 | Paye | Kwity | IND | DE | Michigan | |||
| 2021 | 1 | 22 | 22 | Farley | Caleb | TEN | CB | Virginia Tech | |||
| 2021 | 1 | 23 | 23 | Darrisaw | Christian | MIN | OT | Virginia Tech | from Jets via Seahawks | ||
| 2021 | 1 | 24 | 24 | Harris | Najee | PIT | RB | Alabama | |||
| 2021 | 1 | 25 | 25 | Etienne | Travis | JAC | RB | Clemson | from Rams | ||
| 2021 | 1 | 26 | 26 | Newsome | Greg | CLE | CB | Northwestern | |||
| 2021 | 1 | 27 | 27 | Bateman | Rashod | BAL | WR | Minnesota | |||
| 2021 | 1 | 28 | 28 | Turner | Payton | NO | DE | Houston | |||
| 2021 | 1 | 29 | 29 | Stokes | Eric | GB | CB | Georgia | |||
| 2021 | 1 | 30 | 30 | Rousseau | Gregory | BUF | DE | Miami | |||
| 2021 | 1 | 31 | 31 | Oweh | Jayson | BAL | DE | Penn State | from Chiefs | ||
| 2021 | 1 | 32 | 32 | Tryon | Joe | TB | LB | Washington | |||
| 2021 | 2 | 1 | 33 | Campbell | Tyson | JAC | CB | Georgia | |||
| 2021 | 2 | 2 | 34 | Moore | Elijah | NYJ | WR | Ole Miss | |||
| 2021 | 2 | 3 | 35 | Williams | Javonte | DEN | RB | North Carolina | from Falcons | ||
| 2021 | 2 | 4 | 36 | Holland | Jevon | MIA | S | Oregon | from Texans | ||
| 2021 | 2 | 5 | 37 | Dickerson | Landon | PHI | C | Alabama | |||
| 2021 | 2 | 6 | 38 | Barmore | Christian | NE | DT | Alabama | from Bengals | ||
| 2021 | 2 | 7 | 39 | Jenkins | Teven | CHI | OT | Oklahoma State | from Panthers | ||
| 2021 | 2 | 8 | 40 | Grant | Richie | ATL | S | UCF | from Broncos | ||
| 2021 | 2 | 9 | 41 | Onwuzurike | Levi | DET | DT | Washington | |||
| 2021 | 2 | 10 | 42 | Eichenberg | Liam | MIA | OT | Notre Dame | from Giants | ||
| 2021 | 2 | 11 | 43 | Moehrig | Trevon | LV | S | TCU | from 49ers | ||
| 2021 | 2 | 12 | 44 | Joseph | Kelvin | DAL | CB | Kentucky | |||
| 2021 | 2 | 13 | 45 | Little | Walker | JAC | OT | Stanford | from Vikings | ||
| 2021 | 2 | 14 | 46 | Carman | Jackson | CIN | OT | Clemson | from Patriots | ||
| 2021 | 2 | 15 | 47 | Samuel | Asante | LAC | CB | Florida State | |||
| 2021 | 2 | 16 | 48 | Banks | Aaron | SF | G | Notre Dame | from Raiders | ||
| 2021 | 2 | 17 | 49 | Moore | Rondale | ARI | WR | Purdue | |||
| 2021 | 2 | 18 | 50 | Ojulari | Azeez | NYG | LB | Georgia | from Dolphins | ||
| 2021 | 2 | 19 | 51 | Cosmi | Samuel | WAS | OT | Texas | |||
| 2021 | 2 | 20 | 52 | Owusu-Koramoah | Jeremiah | CLE | LB | Notre Dame | from Bears via Panthers | ||
| 2021 | 2 | 21 | 53 | Radunz | Dillon | TEN | OT | North Dakota State | |||
| 2021 | 2 | 22 | 54 | Odeyingbo | Dayo | IND | DE | Vanderbilt | |||
| 2021 | 2 | 23 | 55 | Freiermuth | Pat | PIT | TE | Penn State | |||
| 2021 | 2 | 24 | 56 | Eskridge | D’Wayne | SEA | WR | Western Michigan | |||
| 2021 | 2 | 25 | 57 | Atwell | Tutu | LAR | WR | Louisville | |||
| 2021 | 2 | 26 | 58 | Bolton | Nick | KC | LB | Missouri | from Ravens | ||
| 2021 | 2 | 27 | 59 | Marshall | Terrace | CAR | WR | LSU | from Browns | ||
| 2021 | 2 | 28 | 60 | Werner | Pete | NO | LB | Ohio State | |||
| 2021 | 2 | 29 | 61 | Basham | Carlos | BUF | DE | Wake Forest | |||
| 2021 | 2 | 30 | 62 | Myers | Josh | GB | C | Ohio State | |||
| 2021 | 2 | 31 | 63 | Humphrey | Creed | KC | C | Oklahoma | |||
| 2021 | 2 | 32 | 64 | Trask | Kyle | TB | QB | Florida | |||
| 2021 | 3 | 1 | 65 | Cisco | Andre | JAC | S | Syracuse | |||
| 2021 | 3 | 2 | 66 | Mond | Kellen | MIN | QB | Texas A&M | from Jets | ||
| 2021 | 3 | 3 | 67 | Mills | Davis | HOU | QB | Stanford | |||
| 2021 | 3 | 4 | 68 | Mayfield | Jalen | ATL | OT | Michigan | |||
| 2021 | 3 | 5 | 69 | Ossai | Joseph | CIN | DE | Texas | |||
| 2021 | 3 | 6 | 70 | Christensen | Brady | CAR | OT | BYU | from Eagles | ||
| 2021 | 3 | 7 | 71 | Robinson | Aaron | NYG | CB | UCF | from Broncos | ||
| 2021 | 3 | 8 | 72 | McNeill | Alim | DET | DT | NC State | |||
| 2021 | 3 | 9 | 73 | Williams | Milton | PHI | DT | Lousiana Tech | from Panthers | ||
| 2021 | 3 | 10 | 74 | St-Juste | Benjamin | WAS | CB | Minnesota | from 49ers | ||
| 2021 | 3 | 11 | 75 | Odighizuwa | Osa | DAL | DT | UCLA | |||
| 2021 | 3 | 12 | 76 | Adebo | Paulson | NO | CB | Stanford | from Giants | ||
| 2021 | 3 | 13 | 77 | Palmer | Josh | LAC | WR | Tennessee | |||
| 2021 | 3 | 14 | 78 | Surratt | Chazz | MIN | LB | North Carolina | |||
| 2021 | 3 | 15 | 79 | Koonce | Malcolm | LV | LB | Buffalo | from Cardinals | ||
| 2021 | 3 | 16 | 80 | Deablo | Divine | LV | S | Virginia Tech | |||
| 2021 | 3 | 17 | 81 | Long | Hunter | MIA | TE | Boston College | |||
| 2021 | 3 | 18 | 82 | Brown | Dyami | WAS | WR | North Carolina | |||
| 2021 | 3 | 19 | 83 | Tremble | Tommy | CAR | TE | Notre Dame | from Bears | ||
| 2021 | 3 | 20 | 84 | Golston | Chauncey | DAL | DE | Iowa | from Eagles via Colts | ||
| 2021 | 3 | 21 | 85 | Rodgers | Amari | GB | WR | Clemson | from Titans | ||
| 2021 | 3 | 22 | 86 | Davis | Wyatt | MIN | G | Ohio State | from Jets via Seahawks | ||
| 2021 | 3 | 23 | 87 | Green | Kendrick | PIT | G | Illinois | |||
| 2021 | 3 | 24 | 88 | Sermon | Trey | SF | RB | Ohio State | from Rams | ||
| 2021 | 3 | 25 | 89 | Collins | Nico | HOU | WR | Michigan | from Browns via Panthers | ||
| 2021 | 3 | 26 | 90 | Jones | Patrick | MIN | DE | Pittsburgh | from Ravens | ||
| 2021 | 3 | 27 | 91 | Schwartz | Anthony | CLE | WR | Auburn | from Saints | ||
| 2021 | 3 | 28 | 92 | Rice | Monty | TEN | LB | Georgia | from Packers | ||
| 2021 | 3 | 29 | 93 | Brown | Spencer | BUF | OT | Northern Iowa | |||
| 2021 | 3 | 30 | 94 | Cleveland | Ben | BAL | G | Georgia | from Chiefs | ||
| 2021 | 3 | 31 | 95 | Hainsey | Robert | TB | G | Notre Dame | |||
| 2021 | 3 | 32 | 96 | Perkins | Ronnie | NE | DE | Oklahoma | compensatory selection | ||
| 2021 | 3 | 33 | 97 | McKitty | Tre’ | LAC | TE | Georgia | compensatory selection | ||
| 2021 | 3 | 34 | 98 | Meinerz | Quinn | DEN | G | Wisconsin-Whitewater | from Saints | ||
| 2021 | 3 | 35 | 99 | Wright | Nahshon | DAL | CB | Oregon State | compensatory selection | ||
| 2021 | 3 | 36 | 100 | Molden | Elijah | TEN | CB | Washington | compensatory selection | ||
| 2021 | 3 | 37 | 101 | Melifonwu | Ifeatu | DET | CB | Syracuse | compensatory selection from Rams | ||
| 2021 | 3 | 38 | 102 | Thomas | Ambry | SF | CB | Michigan | special compensatory selection | ||
| 2021 | 3 | 39 | 103 | Jones | Ernest | LAR | LB | South Carolina | special compensatory selection | ||
| 2021 | 3 | 40 | 104 | Stephens | Brandon | BAL | CB | SMU | special compensatory selection | ||
| 2021 | 3 | 41 | 105 | Browning | Baron | DEN | LB | Ohio State | from Saints | ||
| 2021 | 4 | 1 | 106 | Tufele | Jay | JAC | DT | USC | |||
| 2021 | 4 | 2 | 107 | Carter | Michael | NYJ | RB | North Carolina | |||
| 2021 | 4 | 3 | 108 | Hall | Darren | ATL | CB | San Diego State | |||
| 2021 | 4 | 4 | 109 | Fitzpatrick | Dez | TEN | WR | Louisville | from Texans via Panthers | ||
| 2021 | 4 | 5 | 110 | Hudson | James | CLE | OT | Cincinnati | from Eagles | ||
| 2021 | 4 | 6 | 111 | Sample | Cameron | CIN | DE | Tulane | |||
| 2021 | 4 | 7 | 112 | St.Brown | Amon-Ra | DET | WR | USC | |||
| 2021 | 4 | 8 | 113 | Barnes | Derrick | DET | LB | Purdue | from Panthers via Browns | ||
| 2021 | 4 | 9 | 114 | Dalman | Drew | ATL | C | Stanford | from Broncos | ||
| 2021 | 4 | 10 | 115 | Cox | Jabril | DAL | LB | LSU | |||
| 2021 | 4 | 11 | 116 | Smith | Elerson | NYG | LB | Northern Iowa | |||
| 2021 | 4 | 12 | 117 | Brown | Bobby | LAR | DT | Texas A&M | from 49ers | ||
| 2021 | 4 | 13 | 118 | Rumph | Chris | LAC | LB | Duke | |||
| 2021 | 4 | 14 | 119 | Nwangwu | Kene | MIN | RB | Iowa State | |||
| 2021 | 4 | 15 | 120 | Stevenson | Rhamondre | NE | RB | Oklahoma | |||
| 2021 | 4 | 16 | 121 | Smith | Jordan | JAC | DE | UAB | from Raiders via 49ers and Rams | ||
| 2021 | 4 | 17 | 122 | Shelvin | Tyler | CIN | DT | LSU | from Cardinals via Texans and Patriots | ||
| 2021 | 4 | 18 | 123 | McPhearson | Zech | PHI | CB | Texas Tech | from Dolphins | ||
| 2021 | 4 | 19 | 124 | Bates | John | WAS | TE | Boise State | |||
| 2021 | 4 | 20 | 125 | Bynum | Camryn | MIN | CB | California | from Bears | ||
| 2021 | 4 | 21 | 126 | Hubbard | Chuba | CAR | RB | Oklahoma State | from Titans | ||
| 2021 | 4 | 22 | 127 | Granson | Kylen | IND | TE | SMU | |||
| 2021 | 4 | 23 | 128 | Moore | Dan | PIT | OT | Texas A&M | |||
| 2021 | 4 | 24 | 129 | Darden | Jaelon | TB | WR | North Texas | from Seahawks | ||
| 2021 | 4 | 25 | 130 | Rochell | Robert | LAR | CB | Central Arkansas | from Rams via Jaguars | ||
| 2021 | 4 | 26 | 131 | Wallace | Tylan | BAL | WR | Oklahoma State | |||
| 2021 | 4 | 27 | 132 | Togiai | Tommy | CLE | DT | Ohio State | |||
| 2021 | 4 | 28 | 133 | Book | Ian | NO | QB | Notre Dame | |||
| 2021 | 4 | 29 | 134 | Robinson | Janarius | MIN | DE | Florida State | from Bills | ||
| 2021 | 4 | 30 | 135 | Weaver | Rashad | TEN | DE | Pittsburgh | from Packers | ||
| 2021 | 4 | 31 | 136 | Wilson | Marco | ARI | CB | Florida | from Chiefs via Ravens | ||
| 2021 | 4 | 32 | 137 | Brown | Tre | SEA | CB | Oklahoma | from Buccaneers | ||
| 2021 | 4 | 33 | 138 | Ball | Josh | DAL | OT | Marshall | compensatory selection | ||
| 2021 | 4 | 34 | 139 | Smith | D’Ante | CIN | OT | East Carolina | from Patriots | ||
| 2021 | 4 | 35 | 140 | Johnson | Buddy | PIT | ILB | Texas A&M | compensatory selection | ||
| 2021 | 4 | 36 | 141 | Harris | Jacob | LAR | WR | UCF | compensatory selection | ||
| 2021 | 4 | 37 | 142 | Newman | Royce | GB | OG | Ole Miss | compensatory selection | ||
| 2021 | 4 | 38 | 143 | Gillespie | Tyree | LV | S | Missouri | from Vikings via Jets | ||
| 2021 | 4 | 39 | 144 | Kaindoh | Joshua | KC | DE | Florida State | compensatory selection | ||
| 2021 | 5 | 1 | 145 | Farrell | Luke | JAC | TE | Ohio State | |||
| 2021 | 5 | 2 | 146 | Sherwood | Jamien | NYJ | S | Auburn | |||
| 2021 | 5 | 3 | 147 | Jordan | Brevin | HOU | TE | Miami | |||
| 2021 | 5 | 4 | 148 | Graham | Ta’Quon | ATL | DT | Texas | |||
| 2021 | 5 | 5 | 149 | McPherson | Evan | CIN | K | Florida | |||
| 2021 | 5 | 6 | 150 | Gainwell | Kenneth | PHI | RB | Memphis | |||
| 2021 | 5 | 7 | 151 | Borom | Larry | CHI | OT | Missouri | from Panthers | ||
| 2021 | 5 | 8 | 152 | Sterns | Caden | DEN | S | Texas | |||
| 2021 | 5 | 9 | 153 | Fields | Tony | CLE | LB | West Virginia | from Lions | ||
| 2021 | 5 | 10 | 154 | Carter | Michael | NYJ | S | Duke | from Giants | ||
| 2021 | 5 | 11 | 155 | Moore | Jaylon | SF | OG | Western Michigan | |||
| 2021 | 5 | 12 | 156 | Loudermilk | Isaiahh | PIT | DT | Wisconsin | from Cowboys via PHI and Dolphins | ||
| 2021 | 5 | 13 | 157 | Smith-Marsette | Ihmir | MIN | WR | Iowa | |||
| 2021 | 5 | 14 | 158 | Nixon | Daviyon | CAR | DT | Iowa | from from Patriots via Texans | ||
| 2021 | 5 | 15 | 159 | James | Brendan | LAC | OT | Nebraska | |||
| 2021 | 5 | 16 | 160 | Wade | Shaune | BAL | CB | Ohio State | from Cardinals | ||
| 2021 | 5 | 17 | 161 | Doyle | Tommy | BUF | OT | Miami (OH) | from Raiders | ||
| 2021 | 5 | 18 | 162 | Gray | Noah | KC | TE | Duke | from Dolphins via Raiders and Jets | ||
| 2021 | 5 | 19 | 163 | Forrest | Darrick | WAS | S | Cincinnati | |||
| 2021 | 5 | 20 | 164 | Johnson | Jamar | DEN | S | Indiana | from Bears via Giants | ||
| 2021 | 5 | 21 | 165 | Davis | Shawn | IND | S | Florida | |||
| 2021 | 5 | 22 | 166 | Taylor | Keith | CAR | CB | Washington | from Titans | ||
| 2021 | 5 | 23 | 167 | Hobbs | Nate | LV | CB | Illinois | from Seahawks | ||
| 2021 | 5 | 24 | 168 | Davidson | Zach | MIN | TE | Central Missouri | from Steelers via Ravens | ||
| 2021 | 5 | 25 | 169 | LeCounte | Richard | CLE | S | Georgia | from Rams | ||
| 2021 | 5 | 26 | 170 | Wallow | Garret | HOU | LB | TCU | from Browns via Jaguars and Rams | ||
| 2021 | 5 | 27 | 171 | Hayes | Daelin | BAL | DE | Notre Dame | |||
| 2021 | 5 | 28 | 172 | Lenoir | Deommodore | SF | CB | Oregon | from Saints | ||
| 2021 | 5 | 29 | 173 | Slaton | Tedarrell | GB | DT | Florida | |||
| 2021 | 5 | 30 | 174 | Brown | Earnest | LAR | DE | Northwestern | from Bills via Texans | ||
| 2021 | 5 | 31 | 175 | Pinnock | Jason | NYJ | CB | Pittsburgh | from Chiefs | ||
| 2021 | 5 | 32 | 176 | Britt | K.J. | TB | LB | Auburn | |||
| 2021 | 5 | 33 | 177 | McGrone | Cameron | NE | LB | Michigan | compensatory selection | ||
| 2021 | 5 | 34 | 178 | Jean-Charles | Shemar | GB | CB | Appalachian State | compensatory selection | ||
| 2021 | 5 | 35 | 179 | Fehoko | Simi | DAL | WR | Stanford | compensatory selection | ||
| 2021 | 5 | 36 | 180 | Huganga | Talanoa | SF | S | USC | compensatory selection | ||
| 2021 | 5 | 37 | 181 | Powell | Cornell | KC | WR | Clemson | compensatory selection | ||
| 2021 | 5 | 38 | 182 | Ogundeji | Adetokunbo | ATL | DE | Notre Dame | compensatory selection | ||
| 2021 | 5 | 39 | 183 | Williams | Avery | ATL | CB | Boise State | compensatory selection | ||
| 2021 | 5 | 40 | 184 | Mason | Ben | BAL | FB | Michigan | compensatory selection | ||
| 2021 | 6 | 1 | 185 | Niemann | Nick | LAC | LB | Iowa | from Jaguars via Titans | ||
| 2021 | 6 | 2 | 186 | Nasirildeen | Hamsah | NYJ | S | Florida State | |||
| 2021 | 6 | 3 | 187 | Darby | Frank | ATL | WR | Arizona State | |||
| 2021 | 6 | 4 | 188 | Bledsoe | Joshua | NE | S | Missouri | from Texans | ||
| 2021 | 6 | 5 | 189 | Tuipulotu | Marlon | PHI | DT | USC | |||
| 2021 | 6 | 6 | 190 | Hill | Trey | CIN | C | Georgia | |||
| 2021 | 6 | 7 | 191 | Jackson | Tarron | PHI | DE | Coastal Carolina | from Broncos via Panthers | ||
| 2021 | 6 | 8 | 192 | Bohanna | Quinton | DAL | DT | Kentucky | from Lions | ||
| 2021 | 6 | 9 | 193 | Brown | Deonte | CAR | OG | Alabama | |||
| 2021 | 6 | 10 | 194 | Mitchell | Elijah | SF | RB | Louisiana | |||
| 2021 | 6 | 11 | 195 | Lopez | Roy | HOU | DT | Arizona | from Cowboys via Patriots | ||
| 2021 | 6 | 12 | 196 | Brightwell | Gary | NYG | RB | Arizona | |||
| 2021 | 6 | 13 | 197 | Sherman | William | NE | OT | Colorado | |||
| 2021 | 6 | 14 | 198 | Rountree | Larry | LAC | RB | Missouri | |||
| 2021 | 6 | 15 | 199 | Twyman | Jaylen | MIN | DT | Pittsburgh | |||
| 2021 | 6 | 16 | 200 | Echols | Brandin | NYJ | CB | Kentucky | from Raiders | ||
| 2021 | 6 | 17 | 201 | Williams | Rodarius | NYG | CB | Oklahoma State | from Cardinals | ||
| 2021 | 6 | 18 | 202 | Evans | Chris | CIN | RB | Michigan | from Dolphins via Texans | ||
| 2021 | 6 | 19 | 203 | Stevenson | Marquez | BUF | WR | Houston | from Football Team via Raiders, Dolphins, and Texans | ||
| 2021 | 6 | 20 | 204 | Smith | Shi | CAR | WR | South Carolina | from Bears | ||
| 2021 | 6 | 21 | 205 | McMath | Racey | TEN | WR | LSU | |||
| 2021 | 6 | 22 | 206 | Young | Landon | NO | OT | Kentucky | from Colts | ||
| 2021 | 6 | 23 | 207 | Marshall | Jonathan | NYJ | DT | Arkansas | from Steelers via Dolphins and Chiefs | ||
| 2021 | 6 | 24 | 208 | Forsythe | Stone | SEA | OT | Florida | from Seahawks via Dolphins and Bears | ||
| 2021 | 6 | 25 | 209 | Camp | Jalen | JAC | WR | Georgia Tech | from Rams | ||
| 2021 | 6 | 26 | 210 | Dimukeje | Victor | ARI | DE | Duke | from Ravens | ||
| 2021 | 6 | 27 | 211 | Felton | Demetric | CLE | WR | UCLA | |||
| 2021 | 6 | 28 | 212 | Hamlin | Damar | BUF | S | Pittsburgh | from Saints via Texans | ||
| 2021 | 6 | 29 | 213 | Wildgoose | Rachad | BUF | CB | Wisconsin | |||
| 2021 | 6 | 30 | 214 | Van Lanen | Cole | GB | OT | Wisconsin | |||
| 2021 | 6 | 31 | 215 | Breeze | Brady | TEN | S | Oregon | from Chiefs | ||
| 2021 | 6 | 32 | 216 | Roche | Quincy | PIT | LB | Miami | from Buccaneers | ||
| 2021 | 6 | 33 | 217 | Herbert | Khalil | CHI | RB | Virginia Tech | from Buccaneers via Seahawks | ||
| 2021 | 6 | 34 | 218 | Ehlinger | Sam | IND | QB | Texas | from Saints | ||
| 2021 | 6 | 35 | 219 | Williams | Seth | DEN | WR | Auburn | from Falcons | ||
| 2021 | 6 | 36 | 220 | McDuffie | Isaiah | GB | LB | Boston College | compensatory selection | ||
| 2021 | 6 | 37 | 221 | Newsome | Dazz | CHI | WR | North Carolina | compensatory selection | ||
| 2021 | 6 | 38 | 222 | Fletcher | Thomas | CAR | LS | Alabama | compensatory selection | ||
| 2021 | 6 | 39 | 223 | Gowan | Tay | ARI | CB | UCF | compensatory selection from Vikings | ||
| 2021 | 6 | 40 | 224 | Stevens | JaCoby | PHI | S | LSU | compensatory selection | ||
| 2021 | 6 | 41 | 225 | Cheeseman | Camaron | WAS | LS | Michigan | from Eagles | ||
| 2021 | 6 | 42 | 226 | Smith | Trey | KC | G | Tennessee | from Panthers via Jets | ||
| 2021 | 6 | 43 | 227 | Mukuamu | Israel | DAL | CB | South Carolina | compensatory selection | ||
| 2021 | 6 | 44 | 228 | Graham | Thomas | CHI | CB | Oregon | compensatory selection | ||
| 2021 | 7 | 1 | 229 | Strachan | Mike | IND | WR | Charleston (WV) | from Jaguars via Saints | ||
| 2021 | 7 | 2 | 230 | Morrissey | Jimmy | LV | C | Pittsburgh | from Jets via 49ers | ||
| 2021 | 7 | 3 | 231 | Coleman | Larnel | MIA | OT | UMass | from Texans | ||
| 2021 | 7 | 4 | 232 | Hoskins | Phil | CAR | DT | Kentucky | from Falcons via Dolphins and Titans | ||
| 2021 | 7 | 5 | 233 | Funk | Jake | LAR | RB | Maryland | from Bengals via Texans | ||
| 2021 | 7 | 6 | 234 | Johnson | Patrick | PHI | OLB | Tulane | |||
| 2021 | 7 | 7 | 235 | Hubert | Wyatt | CIN | DE | Kansas State | from Lions via Seahawks | ||
| 2021 | 7 | 8 | 236 | Anderson | Jack | BUF | OG | Texas Tech | from Panthers | ||
| 2021 | 7 | 9 | 237 | Vincent | Kary | DEN | CB | LSU | |||
| 2021 | 7 | 10 | 238 | Farniok | Matt | DAL | G | Nebraska | |||
| 2021 | 7 | 11 | 239 | Cooper | Jonathan | DEN | DE | Ohio State | from Giants | ||
| 2021 | 7 | 12 | 240 | Bradley-King | William | WAS | DE | Baylor | from 49ers via PHI | ||
| 2021 | 7 | 13 | 241 | Webb | Mark | LAC | S | Georgia | |||
| 2021 | 7 | 14 | 242 | Nixon | Tre | NE | WR | UCF | |||
| 2021 | 7 | 15 | 243 | Wiggins | James | ARI | S | Cincinnati | |||
| 2021 | 7 | 16 | 244 | Doaks | Gerrid | MIA | RB | Cincinnati | from Football Team via Raiders | ||
| 2021 | 7 | 17 | 245 | Norwood | Tre | PIT | CB | Oklahoma | from Dolphins | ||
| 2021 | 7 | 18 | 246 | Toney | Shaka | WAS | DE | Penn State | |||
| 2021 | 7 | 19 | 247 | Menet | Michal | ARI | C | Penn State | from Bears via Raiders | ||
| 2021 | 7 | 20 | 248 | Fries | Will | IND | OT | Penn State | |||
| 2021 | 7 | 21 | 249 | Skowronek | Ben | LAR | WR | Notre Dame | from Titans via Jaguars | ||
| 2021 | 7 | 22 | 250 | Tonga | Khyiris | CHI | DT | BYU | from Seahawks | ||
| 2021 | 7 | 23 | 251 | Wilcox | Chris | TB | CB | BYU | from Steelers | ||
| 2021 | 7 | 24 | 252 | Garrett | Chris | LAR | LB | Concordia University St Paul- | |||
| 2021 | 7 | 25 | 253 | Spencer | Marquiss | DEN | DE | Mississippi State | from Browns | ||
| 2021 | 7 | 26 | 254 | Harvin | Pressley | PIT | P | Georgia Tech | from Ravens | ||
| 2021 | 7 | 27 | 255 | Baker | Kawaan | NO | WR | South Alabama | |||
| 2021 | 7 | 28 | 256 | Hill | Kylin | GB | RB | Mississippi State | |||
| 2021 | 7 | 29 | 257 | Jefferson | Jermar | DET | RB | Oregon State | from Bills via Browns | ||
| 2021 | 7 | 30 | 258 | Milne | Dax | WAS | WR | BYU | from Chiefs via Dolphins | ||
| 2021 | 7 | 31 | 259 | Stuard | Grant | TB | LB | Houston | |||